Blog

Breaking Down CBD: A Guide To How Our Bodies Metabolize This Cannabinoid

Tuesday, October 17th, 2017
cannabidiol

How is CBD Metabolized?

 

For even committed students of CBD, many don’t understand the metabolic processes involved in its consumption. While there is plenty of literature out there with a more technical focus, there are very few resources out there to communicate that focus in a plain way. In this article, we’ll review your body’s natural metabolic processes, and how CBD is broken down specifically.

What is Metabolism, Anyway?

Metabolism is the conversion of one chemical compound into another through enzymes. Enzymes are proteins that live within your body’s cells that speed up chemical reactions.

 

 

Most of your body’s metabolism happens in the gut wall, lungs, and blood plasma.

 

The main enzymes in metabolism are a part of the “cytochrome P450” group, which will be of importance later.

 

Metabolism is divided into two phases  – 1 and 2. In phase 1 metabolism, your body goes through oxidation and sheds electrons from whatever you’ve taken. After phase 1, the drug is said to be “oxidized.”

 

In phase 2, the drug becomes more water soluble, making it possible to expel the drug from your system. The drug also loses pharmacological activity during this time. Think – something leaves your body and becomes less effective.

 

To review, you take something, say CBD Capsules, and they enter your system. They make it to your liver, which is the processing center for the body. Two phases of chemical reactions occur and the drug loses its effect. After the end of the second metabolism phase, the CBD capsules are water soluble enough that they can be expelled from your system.

How is CBD Broken Down?

The first thing to say on CBD metabolism, is that it is very important to understand how CBD is broken down and how it interacts with other drugs in your system. As CBD moves into the liver and becomes metabolized, it is converted in a chemical compound 7-hydroxy-CBD

(7-OH-CBD), and may also be converted into 6-OH-CBD.

 cbd capsules

At this time, little is known about these metabolites, the leftovers of CBD metabolism. However, a derivative from this process, called D2 (E) Valproate, has anticonvulsant properties that might also be involved in the antiepileptic effects of CBD.

Cytochrome P450

Earlier in the article, we mentioned the importance of cytochrome P450, the group of enzymes mainly responsible for the liver’s metabolism. In CBD metabolism, CBD seems to have an inhibiting effect on these enzymes. Through this inhibitory effect, CBD prevents cytochrome P450 from metabolizing other compounds.

 blood

Now, this inhibitory effect can fluctuate with dosage, the individual, and how tightly CBD binds to cytochrome p450 before and after oxidation.

 

In clinical trials, as little as 25 mg of orally administered CBD, like the capsules we mentioned earlier, blocked the metabolism of an antiepileptic drug.

 

For consumers, this means that CBD can have potential reductive effects on other medications you may be taking. Be sure to consult your physician on the status of your individual metabolism.

The More You Know

Like many other industries, CBD is evolving. While there is much more information circulating now than ever before, there’s still much we don’t know about CBD, as evidenced by its metabolic processes. Truly, after CBD begins to metabolize within your body, we don’t know whether metabolites help or hurt its pre-metabolic effects. The more you know, the better decisions you make when it comes to your own consumption.

slider_hempbombs-feel-great-relax-now-1600x378px

Latest posts

powdered cannabis

DIY Cannabis Powder…It’s A Game Changer

Wednesday, May 2nd, 2018
We all like to get high on quality cannabis products. If you are not smoking pot, you are probably consuming it as an edible. Every stoner or any regular cannabis user know their limit. Whether they are consuming it for recreational purposes or for its medicinal value. The main problem comes when one overdoses’ of cannabis. This may happen to new cannabis edibles consumers. For new users wanting a more regulated experience, powdered cannabis may be an answer.
View all posts

Latest Videos

CBD Oil

Tips to Getting the Right CBD Oil Dosage

Monday, January 22nd, 2018
One of the biggest concerns with medical marijuana is getting the correct dosage of healing cannabinoids. In most oils or dried flowers, it is almost impossible to determine the amount of active ingredients in each dose. Fortunately, there is a better, more precise alternative
View all videos

POT ETIQUETTE TESTIMONIALS

WHAT OUR VISITORS HAVE TO SAY

This site has taught me what marijuana can do. It has got me so fucking high. Thanks for the rolling tips, they really work!
~ KAREEM TATEM
I came across this site by mistake, lol, looking for a good brownie recipe. I LOVE THIS SITE!!! You are now my personal HERO!!!!
~ MRS. LEONARD
I absolutely adore this pot etiquette site. As a college student getting high is a regular part of life. Because of your advice I am now able to eat a brownie before class, and comprehend the material better. Thanxs for an awesome fuckin site.
~ BIA MAL